At Regenexx Australia, we offer nonsurgical alternatives to treat knee pain and knee injuries.
Both acute and chronic knee injuries can cause pain during exercise, with day-to-day activities, or even at night. If you have one of the knee conditions below, you may benefit from our treatment options.
In a study from 2013, 15 patients with knee osteoarthritis of up to grade II on the Kellgren Lawrence scale were given 1 injection of PRP. The patients were assessed with an MRI 12 months later and 73% showed no further loss of articular cartilage in any compartment. This is despite it being generally accepted that most patients with symptomatic knee osteoarthritis loose between 3% and 5% of their knee articular cartilage each year. In the study, the patients’ pain scores decreased, and functional and clinical score increased at 6 and 12 months after the one injection.
A meta-analysis from the same year that pooled the data from 16 studies looking at over 1500 patients found “PRP injection significantly improved the functional status… in patients with knee degenerative pathology, and the beneficial effect was maintained for 1 year after treatment.”
A further meta-analysis published in 2021 reviewing 32 studies and looking at over 1600 patients confirmed injections of PRP produced “improvements above the MCID (minimal clinically important difference) in terms of pain and function in patients with knee OA up to 12 months”.
Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J. Clin J Sport Med. 2013 May;23(3):238-9.
Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years. Anita E Wluka, Andrew Forbes, Yuanyuan Wang, Fahad Hanna, Graeme Jones and Flavia M Cicuttini. Arthritis Research & Therapy 2006, 8:R90
Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. Chang KV, Hung CY, Aliwarga F, Wang TG, Han DS, Chen WS. Arch Phys Med Rehabil. 2014 Mar;95(3):562-75. doi: 10.1016/j.apmr.2013.11.006. Epub 2013 Nov 27. PMID: 24291594.
Adverse Reactions and Clinical Outcomes for Leukocyte-Poor Versus Leukocyte-Rich Platelet-Rich Plasma in Knee Osteoarthritis: A Systematic Review and Meta-analysis. Kim JH, Park YB, Ha CW, Roh YJ, Park JG. Orthop J Sports Med. 2021 Jun 30;9(6):23259671211011948. doi: 10.1177/23259671211011948. PMID: 34277879; PMCID: PMC8255589.
If you are an active person with pain in your knee, contact us to see how we can help.